There are numerous strategies that can be applied when developing combination products with soluble compounds. However, new strategies will have to be used by considering combinations with soluble and insoluble compounds. Different physical phases will have to be used to achieve the greatest pharmacokinetic profile for a number of such Active Pharmaceutical Ingredients. This will result in the need for multi-phase delivery system to deliver them. Each compartment is sealed to prevent the medicaments from escaping and coming into contact with one another. New capsule technologies: Innercap Technologies, Intestinal pressure-controlled colon delivery capsules, Colonic drug delivery system based on pectin and galactomannan coating, Azo hydrogels, Colon Targeted Delivery System, Implantable insulin pump in form of capsule and Pulsed release capsule device. Evaluation tests of the innovative capsules can be performed by weight variations, content uniformity, compatibility testing, disintegration time, lag time, in-vitro drug release, water uptake studies, rheological analysis, thermal analysis and critical Stability study. The release profile can be modulated with modification in the shell materials or coatings can be applied to target or control the release of medicaments from the compartments. Also release profile can be depended to the active compounds filled into each capsule in a number of ways.
Loading....